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Angiopoietins and angiopoietin-like proteins in angiogenesis

PostPosted: Fri Sep 22, 2006 10:37 am
by patoco
Angiopoietins and angiopoietin-like proteins in angiogenesis.

March 2006

Morisada T, Kubota Y, Urano T, Suda T, Oike Y.

Department of Cell Differentiation, The Sakaguchi Laboratory, School of
Medicine, Keio University, Tokyo, Japan.

Vascular network formation requires several endothelial cell growth
factors. These factors have a potent angiogenic effect, and their
precise coordination is essential for vascular development. Among them,
angiopoietins function through the Tie2 receptor, whose signaling is
critical to regulate vascular stabilization and remodeling. It has been
reported that the angiopoietin/Tie2 signal is involved in survival and
migration of endothelial cells and regulates vascular remodeling and
maintenance of vascular integrity.

More recent studies demonstrate that angiopoietin/Tie2 signaling is also required for lymphangiogenesis. The authors and several other groups have identified six angiopoietin-like proteins (Angptls) containing a coiled-coil domain and a fibrinogen-like domain, both of which are characteristic of angiopoietins.

Interestingly, Angptls also function in angiogenesis
through regulating survival and migration of endothelial cells,
although Angptls do not bind the angiopoietin receptor Tie2. Currently,
Angptls are orphan ligands, but they have been reported to have
pleiotropic effects not only on vascular cells but also on metabolism
and tumor biology. Here, the authors review current findings relating
to the roles of angiopoietins and Angptls in vascular biology and
discuss molecular mechanisms relevant to these factors and

PMID: 16728326 [PubMed - in process] ... med_docsum


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