Prospects and challenges of vaccines against filariasis.

Wuchereria bancrofti vespid, Immune response, Serum immune complexes diagnosis, Diethylcarbamazine (DEC), Wolbachia in filarial parasites, Interdigital skin lesions, Urban Filariasis, Doxycycline, mass drug administration program, Filarial Lymphedema Care, Detection of filarial parasites, Albendazole, research abstracts

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Prospects and challenges of vaccines against filariasis.

Postby patoco » Sun Dec 25, 2011 8:27 am

Future prospects and challenges of vaccines against filariasis.
Dec. 2011

Babayan SA, Allen JE, Taylor DW.

Source

Institute of Infection, Immunology Research Division of Pathway Medicine, University of Edinburgh, Edinburgh EH9 3JT, UK.

Abstract
Filarial infections remain a major public health and socio-economic problem across the tropics, despite considerable effort to reduce disease burden or regionally eliminate the infection with mass drug administration programs. The sustainability of these programs is now open to question due to a range of issues, not least of which is emerging evidence for drug resistance. Vaccination, if developed appropriately, remains the most cost-effective means of long term disease control.

The rationale for the feasibility of vaccination against filarial parasites including onchocerciasis (river blindness, Onchocerca volvulus) and lymphatic filariasis (Wuchereria bancrofti or Brugia malayi) is founded on evidence both from humans and animal models for the development of protective immunity. Nonetheless, enormous challenges need to be faced in terms of overcoming parasite induced suppression without inducing pathology as well as the need to both recognise and tackle evolutionary and ecological obstacles to successful vaccine development.

Nonetheless, new technological advances in addition to systems biology approaches offer hope that optimal immune responses can be induced that will prevent infection, disease and/or transmission.

Blackwell Publishing Ltd.

PubMed

http://www.ncbi.nlm.nih.gov/pubmed/22150082
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