Lymph node fibrosclerosis in primary lymphedema

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Lymph node fibrosclerosis in primary lymphedema

Postby patoco » Thu Jun 15, 2006 12:00 am

Lymph node fibrosclerosis in primary lymphedema

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Following is a series of older articles detailing physiological changes
involved in the lymph nodes of primary lymphedema. This is valuable
information on the deterioration of our lymphatics caused by
long term lymphedema.

The tragedy is the I am not able thus far to find any more recent
updates or research.


Variants and stages of regional lymph nodes sclerosis in lymphedema
[Article in Russian]

April 6, 1998

Maiborodin IV, Shevela AI, Titova LV.

Institute of Clinical and Experimental Lymphology, Novosibirsk.
The inguinal lymph nodes of patients with primary lymphedema of lower
extremities were investigated by light microscopy. It was found that
sclerotization of regional lymph nodes can begin with both cortical and
medullary parenchyma. Different stages of this process in lymph nodes
were distinguished. These stages depend on the duration of the illness
and the zone of organ where the first signs of sclerotization were
observed. Small islands of lymphoid parenchyma were found in even well
advanced sclerosis lymph nodes, and this allows to assume possibility
of full regeneration of all structure of these organs when lymph
circulation is normalized.

PMID: 9612511 [PubMed - indexed for MEDLINE] ... =pubmed&...


Lympho-nodal fibrosclerosis in primary lymphedema. Considerations on lympho-nodal fibrosclerosis in primary lymphedema.

1983 Dec;16

Part One - Abstract

Rada IO, Tudose N, Bibescu Roxin R.

Segments of an inferior inguinal ganglion and of an external iliac
(upper inguinal) ganglion were microscopically examined in 46 cases of
bilateral primary lymphedema and 26 cases of unilateral primary
lymphedema. The examination was performed bilaterally and comparatively to a set of ganglions unaffected by lymphedema, during the years 1974-1978. In all the lymph nodes originating from the patients with lymphedema important morphopathological alternations were noticed, chiefly consisting in fibrosis, fibrosclerosis, fat loading,
hyalinization processes, giganto-cellular responses, etc., leading even
to an aspect of cirrhosis, lympho-nodal pseudo-cirrhosis. These
alterations were also found on the healthy side of the patients with
unilateral primary lymphedema at the time of the microscopical
examination. In the same patient clinical edema appeared in the
following years. The degree of the morphopathological alterations was
greater in the side of the greater edema and more peculiar in the cases
of bulkier edema.

PMID: 6664115 [PubMed - indexed for MEDLINE] ... =PubMed&...

Part Two

The inguinal-iliac lympho-nodal fibrosclerotic processes appearing in
female patients with primary lymphedema bring about an obvious tendency of reduction of the circulatory flux in the afferent lymphatics at some distance from the lympho-nodal area: at the foot or at the shank.

The inguinal lympho-nodal morphopathological alterations (examined in 72 cases of primary lymph-edema) were followed, by distal lymph stasis at the level of the foot and of the leg, without sensibly affecting the
lymph flow in the thigh. These aspects of the lymph stasis adjacent to
the lympho-nodal areas are striking in the patients with secondary

PMID: 6664116 [PubMed - indexed for MEDLINE] ... =PubMed&...


Related Abstracts

Structural and ultrastructural changes of lymph nodes in primary

Tudose N, Rada O.

Optical and electronmicroscopic investigations of the inguino-iliac
lymph nodes and lymphatic vessels of the lower limb suggested a
pathogenic role of lymph node structural alterations in primary

Most of the investigated lymph nodes showed an extensive
fibrosis frequently associated with lipomatosis ectasy of medullary
sinuses, a.o., estimated as primary lesions appearing on a genetically
propensic ground or by developmental anomalies. Alteration of the
lymphatic vessel intima, proliferation, muscle hypertrophy, subintimal
fibrohyalinosis, a.o., occurred in consequence of the impeded lymphatic
drainage by the primary lymph node fibrosis.

PMID: 6231474 [PubMed - indexed for MEDLINE] ... =pubmed&...


Morphological changes of lymphatic system in patients with the
lymphedema of lower extremities

[Article in Russian]
Borodin IuI, Liubarskii MS, Shevela AI, Maiborodin IV, Nimaev VV,
Titova LV, Shumkova OA, Shkurin MA, Pospelov PV.

Morphological changes in inguinal lymph nodes, lymphatic collector and
subcutaneous space were studied up in patients with the lower
extremities lymphoedema. While the lower extremities lymphoedema occurs in inguinal lymph nodes the connective tissues spreading in two
variants is observed. In the first one fibroblasts and collagen fibres
appears in medullar substance (chordae medullaris and medullar sinuses)
and in the second the sclerosis process begins from cortical plateau
and paracortical zone. It is expedient to include the intraarterial
infusion of the xenospleen preparations in complex of treatment of
patients with initial stage of the lower extremities lymphoedema,
especially in the absence of possibility to proceed with microsurgical
intervention and the erysipelas presence in anamnesis.

PMID: 11288238 [PubMed - indexed for MEDLINE] ... =pubmed&...
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Primary Lymphoedema

Postby debbie » Thu Jun 29, 2006 6:48 pm

:D Hi I have been diaognised with Primary Lymphoedema, i have had it since February last year after it was misread in a report of a lymphgram Xray I had done It wasnt picked up until June of last year, anyway, My right foot and leg keep swelling and had a lot of pain, it sometimes causes me not to be able to walk which at times I go beyond the pain barriers to keep my leg under movitated. Times I have to be in the wheelchair which I dont want to, I am on medication for the pain, on fluid pills, span k, have developed burists which has forced me to give up exercising, My family are numb as to what to do or how to help as to this day I am not under a specialist only my GP and Occupational Therapist, I am from Australia, I have a granddaughter and she keeps on my toes. I am not going to let this disease get to me but at times it does, I have cried alot. Some doctors I have been to don't want to know or do anything for me as they are so ignnotate towards people with lymphoedema WHY? I like to see them have a member of their family with this and show them a thing or too. I am currently losing my weight which is great. I know I have a long way to go but I AM A LITTLE FIGHTER AND I KNOW THAT I CAN WIN THIS BATTLE.
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Primary Lymphoedema

Postby patoco » Thu Jun 29, 2006 8:36 pm

Hi Debbie :D

Super welcome to our family :wink: :!: :!: :!:

I don't understand doctors like that...never have. I too have actually had doctors say the they didn't know anything about lymphedema and didn't want to....they need to be in another job...not pretending to care for people that look to them for help :evil: :evil:

I do hope you are able to find treatment. There are some wonderful resources in Australia that probably can help as well.

Please don't ever hesitate to ask any questions, concerns...or even if you just need to vent. Remember, we are all here for each other.

Very much look forward to getting to know you.

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Postby debbie » Fri Jun 30, 2006 8:05 am

:D Hi Pat

Thank You for the warm welcome, it was great to get on here and talk. I have got my family interested in joining up to get information and find out ways to help me get through it. and will give them a better understanding of what I have. I have found out there is a clinic in South Australia called the Flinders Clinic which deals in all type of Lymphoedema. I am looking forward to chatting with other people and get ideas.

kind Regards
debbie :lol:
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Location: australia

Postby silkie » Tue Jul 11, 2006 11:54 pm

Hi Debbie
Big welcome, I have heard of Flinders Uni

There is research dept for lymph there if im not mistaken

If its something to do with the uni at least they will know Lymph there

It is great to talk on here we all know at least some of the problems

and frustrations


Silks xxxx
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