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complications_of_breast_cancer_radiotherapy [2012/01/10 08:39]
Pat O'Connor [Complications of Breast Cancer Radiotherapy]
complications_of_breast_cancer_radiotherapy [2012/10/16 14:40] (current)
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 [[http://​www3.interscience.wiley.com/​cgi-bin/​jhome/​28741?​CRETRY=1&​SRETRY=0 |Cancer 2007; Advance online publication]] [[http://​www3.interscience.wiley.com/​cgi-bin/​jhome/​28741?​CRETRY=1&​SRETRY=0 |Cancer 2007; Advance online publication]]
  
 +======Risk of lymphedema after regional nodal irradiation with breast conservation therapy.======
 +Apr. 2003
  
 +Coen JJ, Taghian AG, Kachnic LA, Assaad SI, Powell SN.
 +
 +**Source**
 +
 +Department of Radiation Oncology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA. [[snpowell@partners.org]]
 +
 +Erratum in
 +Int J Radiat Oncol Biol Phys. 2003 Jun 1;​56(2):​604.
 +
 +**Keywords:​** ​ Radiation, Breast cancer, Lymphedema, Axillary surgery
 +
 +**Abstract**
 +
 +PURPOSE:
 +To evaluate the risk factors for lymphedema in patients receiving breast conservation therapy for early-stage breast cancer.
 +
 +METHODS AND MATERIALS:
 +Between 1982 and 1995, 727 Stage I-II breast cancer patients were treated with breast conservation therapy at Massachusetts General Hospital. A retrospective analysis of the development of persistent arm edema was performed. Lymphedema was defined as a >2-cm difference in forearm circumference compared with the untreated side. The median follow-up was 72 months. Breast and regional nodal irradiation (BRNI) was administered in 32% of the cases and breast irradiation alone in 68%.
 +
 +RESULTS:
 +Persistent arm lymphedema was documented in 21 patients. The 10-year actuarial incidence was 4.1%. The median time to edema was 39 months. The only significant risk factor for lymphedema was BRNI. The 10-year risk was 1.8% for breast irradiation alone vs. 8.9% for BRNI (p = 0.001). The extent of axillary dissection did not predict for lymphedema even within the subgroups of patients defined by the extent of irradiation. Most patients underwent Level I or II dissection. In this subgroup, the lymphedema risk at 10 years was 10.7% for BRNI vs. 1.0% for breast irradiation alone (p = 0.0003).
 +
 +CONCLUSION:
 +Nodal irradiation was the only significant risk factor for arm lymphedema in patients receiving breast conservation therapy for early-stage breast cancer. Our data suggest that this risk is low with Level I/II dissection and breast irradiation. However, even after the addition of radiotherapy to the axilla and supraclavicular fossa, the development of lymphedema was only 1 in 10, lower than generally recognized.
 +
 +[[http://​www.redjournal.org/​article/​S0360-3016(02)04273-6/​abstract|Radiation Oncology]]
 ======External Links====== ======External Links======
  
complications_of_breast_cancer_radiotherapy.txt ยท Last modified: 2012/10/16 14:40 (external edit)