- /poly·neu·rop·a·thy/ (-ndbobr-rop´ah-the) neuropathy of several peripheral nerves simultaneously.
See idiopathic polyradiculoneuritis.
Polyneuropathy associated with amyloidosis, of either the primary or the familial type; symptoms may include dysfunction of the autonomic nervous system, carpal tunnel syndrome, and sensory disturbances in the limbs.
Polyneuropathy - chronic inflammatory; CIDP; Chronic inflammatory demyelinating polyneuropathy; Chronic inflammatory polyneuropathy is nerve inflammation that results in loss of movement or sensation.
A noninflammatory, diffuse loss of myelinated fibers in the distal portions of the central and peripheral nervous systems, resulting in progressive hindlimb ataxia and hypermetria in young Birman kittens. Believed to be inherited as an autosomal recessive trait.
Acrodynia. A disease of early childhood marked by pain and swelling in, and pink coloration of, the fingers and toes and by listlessness, irritability, failure to thrive, profuse perspiration, and sometimes scarlet coloration of the cheeks and tip of the nose. Most cases are toxic neuropathies caused by exposure to mercury.
Autosomal dominant amyloid polyneuropathy, associated with familial amyloidosis and most commonly involving a mutant form of the protein transthyretin (a-globulin secreted by the liver that transports retinol-binding protein and thyroxine in the blood.). It may be subclassified on the basis of affected kinships or on the basis of symptoms and the biochemical composition of the affected fibrils.
Associated with hyperinsulinism of ß-cell insulinomas; there is generalized muscle weakness, paraparesis and tetraparesis.
A progressive lower motor neuron disease associated with hypothyroidism.
See idiopathic polyradiculoneuritis - an acute, progressive ascending paralysis, usually leading to complete tetraplegia, that occurs in dogs and rarely cats. A slow recovery is usual but occasional cases are chronic or relapsing. The condition follows raccoon bites in some dogs, hence the name 'Coonhound paralysis', but the etiology is unclear; other cases occur sporadically with no known cause.
(b) Idiopathic neuropathy is a disorder that affects the peripheral nerves and has no identifiable primary cause. According to this definition, a third of all neuropathies can be classified as idiopathic neuropathies.
Can be divided into two general types. One type, the immune-mediated demyelinating neuropathies, includes Guillain-Barré syndrome (GBS), chronic inflammatory demyelinating polyneuropathy (CIDP), multifocal motor neuropathy (MMN), and related disorders. Myelin seems to be the primary target of the immune attack in these disorders, although axonal variants are known. It is estimated that a large number of patients with CIDP remain undiagnosed and untreated (which emphasizes the importance of review articles on this topic). The other type consists of vasculitic neuropathy (systemic or nonsystemic), which is caused by inflammatory vasculopathy affecting small- and medium-diameter epineurial and perineurial vessels that leads to nerve ischemia or infarcts.
See also: Peripheral neuropathy