Related Infections: Cellulitis, Lymphangitis, Lymphadenitis, Erisypelas, Impetigo, Cat Scratch Fever, Cutaneous Abscesses, Scalded Skin Syndrome, Necrotizing Fascitis, MRSA Methicillin Resistant Staphylococcus Aureus
One must remember that every infection we have further damages our lymphatics, thus leading to more severe lymphedema. Untreated infection will lead to sepsis (commonly refered to as blood poisoning), gangrene which involves loss of limb and/or eventual death.
In treating any type of infection, the doctor not only must identify the type of bacteria involved, but must understand the staging of lymphedema and the differences in the tissue types of the stages.
Heavily fibrotic lymphedema limbs are exceedingly difficult to treat because the denseness of the tissue impeeds or even can prevent the chosen antibiotic from reaching the bacteria. In this situation long term IV antibiotic thereapy should be considered.
See also: Preventing Hospital Infections
Acute Cellulitis is one of the complications of lymphedema. The patient may not be aware of the source of the etiology. Sometimes it may be a cut, mosquito bite, open wound or other infection in the body.
The first sign is increased or different quality of PAIN involving the lymphedema limb. The patients often describe this as a “flu like symptom or an ache” involving the Lymphedema arm or leg. This is usually followed by sudden onset of ERYTHEMA(redness, red streaks or blotches) on the involved limb. The HYPERTHERMIA(lymphedema limb becomes warm, hot) will follow and the patient may experience the CHILLS and even HIGH FEVER.
The early intervention and treatment with antibiotics will resolve this condition (it usually takes a very minimum ten day course of antibiotics). Only a Medical Doctor will be able to prescribe the Antibiotics, thus a consultation with a Doctor is necessary. Severe Cellulitis may require Inter venous Antibiotic treatment and hospitalization. Again, elevation of the affected limb is important.
During that phase the patient should NOT massage the Lymphedema limb, bandage, apply the pump, wear tight elastic sleeve or exercise excessively. Avoid the blood pressure and blood to be drawn from the involved arm. Keep the limb elevated as much as possible while resting. Once the symptoms dissipate the treatment MLD/CDP should be initiated.
How do we prevent this infection? The patient should be careful with daily activities and take all precautions to protect the skin (wear gloves when gardening, cleaning with detergents, etc… ). If an injury to skin occurs on the Lymphedema limb it is necessary to clean the wound with alcohol or hydrogen peroxide and apply Neosporin/Polysporin antibiotic ointment. If the symptoms progress seek the attention of a physician immediately.
Lymphangitis is an inflammation of one or more lymphatic vessels. Generally caused by an acute streptoccocal infection from an insect bite,animal bite of wound. Fine red streaks may extend from the infected area to the armpits or groin. Other signs and symptoms include fever, chills, headache, or muscle ache.
Immediate treatment is required to prevent the infection spreading into the blood stream thereby becoming septic. Treatment is with antibiotic therapy.
Lymphangitis involves the lymph vessels/channels, with inflammation of the channel and resultant pain and systemic and localized symptoms. It commonly results from an acute streptococcal or staphylococcal infection of the skin (cellulitis), or from an abscess in the skin or soft tissues.
Lymphangitis may suggest that an infection is progressing, and should raise concerns of spread of bacteria to the bloodstream, which can cause life-threatening infections. Lymphangitis may be confused with a clot in a vein (thrombophlebitis).
red streaks from infected area to the armpit or groin may be faint or obvious throbbing pain along the affected area (common) may involve the lymph nodes (see above) fever of 100 to 104 degrees Fahrenheit and/or chills individuals may have a general ill feeling (malaise), with loss of appetite, headache, and muscle aches
Lymphadenitis and lymphangitis
Acute lymphangitis is a bacterial infection in the lymphatic vessels which is characterized by painful, red streaks below the skin surface. This is a potentially serious infection which can rapidly spread to the bloodstream and be fatal.
Lymphadenitis and Lymphangitis
Inflammation of lymph nodes.
Etiology Any pathogen–bacterial, viral, protozoal, rickettsial, or fungal–can cause lymphadenitis. Lymph node involvement may be generalized, with systemic infection, or confined to regional lymph nodes draining a local area of infection. Generalized lymph node enlargementis common in infectious mononucleosis, cytomegalovirus infection, toxoplasmosis, brucellosis, secondary syphilis, and disseminated histoplasmosis. Regional lymphadenopathy is prominent in streptococcal disease, TB or nontuberculous mycobacterial disease, tularemia, plague, cat-scratch disease, primary syphilis, lymphogranuloma venereum, chancroid, and genital herpes simplex.
Symptoms, Signs, and Diagnosis Lymph node enlargement from edema and WBC cellular infiltration, the major sign of lymphadenitis, may be asymptomatic or may cause pain and tenderness. With some infections the overlying skin is inflammed, occasionally with cellulitis; abscess formation may occur, and penetration to the skin will produce draining sinuses.
Lymphadenitis and its cause are usually clinically apparent. Occasionally, however, lymph node aspiration and culture or excisional biopsy is necessary.
Treatment Treatment depends on the underlying cause. With resolution of the primary process, lymph node enlargement usually resolves, but firm, nontender lymphadenopathy sometimes persists. Hot, wet dressings may help relieve symptoms of acutely painful lymph nodes. Abscesses require surgical drainage.
Lymphadenitis is the inflammation of a lymph node. It is often a complication of a bacterial infection of a wound, although it can also be caused by viruses or other disease agents. Lymphadenitis may be either generalized, involving a number of lymph nodes; or limited to a few nodes in the area of a localized infection. Lymphadenitis is sometimes accompanied by lymphangitis, which is the inflammation of the lymphatic vessels that connect the lymph nodes.
Lymphadenitis is marked by swollen lymph nodes that are painful, in most cases, when the doctor touches them. If the lymphadenitis is related to an infected wound, the skin over the nodes may be red and warm to the touch. If the lymphatic vessels are also infected, there will be red streaks extending from the wound in the direction of the lymph nodes. In most cases, the infectious organisms are hemolytic Streptococci or Staphylococci. Hemolytic means that the bacteria produce a toxin that destroys red blood cells.
The extensive network of lymphatic vessels throughout the body and their relation to the lymph nodes helps to explain why bacterial infection of the nodes can spread rapidly to or from other parts of the body. Lymphadenitis in children often occurs in the neck area because these lymph nodes are close to the ears and throat, which are frequent locations of bacterial infections in children.
Causes and symptoms
Streptococcal and staphylococcal bacteria are the most common causes of lymphadenitis, although viruses, protozoa, rickettsiae, fungi, and the tuberculosis bacillus can also infect the lymph nodes. Diseases or disorders that involve lymph nodes in specific areas of the body include rabbit fever (tularemia), cat-scratch disease, lymphogranuloma venereum, chancroid, genital herpes, infected acne, dental abscesses, and bubonic plague. In children, tonsillitis or bacterial sore throats are the most common causes of lymphadenitis in the neck area. Diseases that involve lymph nodes throughout the body include mononucleosis, cytomegalovirus infection, toxoplasmosis, and brucellosis.
The early symptoms of lymphadenitis are swelling of the nodes caused by a buildup of tissue fluid and an increased number of white blood cells resulting from the body's response to the infection. Further developments include fever, often as high as 101-102°F (38-39°C) together with chills, loss of appetite, heavy perspiration, a rapid pulse, and general weakness.
The diagnosis of lymphadenitis is usually based on a combination of the patient's history, the external symptoms, and laboratory cultures. The doctor will press (palpate) the affected lymph nodes to see if they are sore or tender. Swollen nodes without soreness are often caused by cat-scratch disease. In children, the doctor will need to rule out mumps, tumors in the neck region, and congenital cysts that resemble swollen lymph nodes.
Although lymphadenitis is usually diagnosed in lymph nodes in the neck, arms, or legs, it can also occur in lymph nodes in the chest or abdomen. If the patient has acutely swollen lymph nodes in the groin, the doctor will need to rule out a hernia in the groin that has failed to reduce (incarcerated inguinal hernia). Hernias occur in 1% of the general population; 85% of patients with hernias are male.
The most significant tests are a white blood cell count (WBC) and a blood culture to identify the organism. A high proportion of immature white blood cells indicates a bacterial infection. Blood cultures may be positive, most often for a species of staphylococcus or streptococcus. In some cases, the doctor may order a biopsy of the lymph node.
The medications given for lymphadenitis vary according to the bacterium or virus that is causing it. If the patient also has lymphangitis, he or she will be treated with antibiotics, usually penicillin G (Pfizerpen, Pentids), nafcillin (Nafcil, Unipen), or cephalosporins. Erythromycin (Eryc, E-Mycin, Erythrocin) is given to patients who are allergic to penicillin.
Supportive care of lymphadenitis includes resting the affected limb and treating the area with hot moist compresses.
Cellulitis associated with lymphadenitis should not be treated surgically because of the risk of spreading the infection. Pus is drained only if there is an abscess and usually after the patient has been started on antibiotic treatment. In some cases, a biopsy of an inflamed lymph node is necessary if no diagnosis has been made and no response to treatment has occurred.
The prognosis for recovery is good if the patient is treated promptly with antibiotics. In most cases, the infection can be brought under control in three or four days. Patients with untreated lymphadenitis may develop blood poisoning (septicemia), which is sometimes fatal.
Symptoms include marked lines of infection, fever, pain, an overall achy feeling and swollen lymph nodes. Most cases involve the legs, and the second largest number of cases involve the face.
Synonyms and related keywords: group A beta-hemolytic streptococci, hemolytic streptococcus
Also includes images
An bacterial infection of the skin beginning as a redness and progressing to itching, blisters, breakdown of the skin, and honey-colored crusts. Lesions usually form on the face and spread locally. The disorder is highly contagious by contact with the discharge from the lesions. Acute kidney trouble is an occasional complication. Treatment includes thorough cleansing with antibacterial soap and water, compresses, removal of crusts and use of systemic antibiotics. Treatment is essential to prevent spread of infection.
Impetigo is a skin disorder caused by bacterial infection and characterized by crusting skin lesions.
Causes, incidence, and risk factors
Impetigo is a common skin infection. It is most common in children, particularly children in unhealthy living conditions. In adults, it may follow other skin disorders. Impetigo may follow a recent upper respiratory infection such as a cold or other viral infection. It is similar to cellulitis, but is more superficial, involving infection of the top layers of the skin with streptococcus (strep), staphylococcus (staph), or both.
The skin normally has many types of bacteria on it, but intact skin is an effective barrier that keeps bacteria from entering and growing within the body. When there is a break in the skin, bacteria can enter the body and grow there, causing inflammation and infection. Breaks in the skin may occur with insect bites, animal bites, or human bites; or other injury or trauma to the skin. Impetigo may occur on skin where there is no visible break.
Impetigo begins as an itchy, red sore that blisters, oozes and finally becomes covered with a tightly adherent crust. It tends to grow and spread. Impetigo is contagious. The infection is carried in the fluid that oozes from the blisters. Rarely, impetigo may form deeper skin ulcers.
Skin lesion on the face/ lips, or on the arms or legs, spreading to other areas. Typically this lesion begins as a cluster of tiny blisters which burst, followed by oozing and the formation of a thick honey or brown colored crust that is firmly stuck to the skin. Itching blister: Filled with yellow or honey-colored fluid Oozing and crusting over Rash (may begin as a single spot, but if child digs at it, it may spread to other areas). In infants, a single or possibly multiple blisters filled with pus, easy to pop and when broken leave a reddish raw-looking base. Lymphadenopathy – local lymph nodes near the infection may be swollen.
Signs and tests
The goal is to cure the infection and relieve the symptoms.
A mild infection is typically treated with a prescription antibacterial cream such as Bactroban. Oral antibiotics (such as erythromycin or dicloxacillin) are also frequently prescribed and result in rapid clearing of the lesions.
Wash the skin several times a day, preferably with an antibacterial soap, to remove crusts and drainage.
Prevent the spread of infection. Use a clean washcloth and towel each time. Do not share towels, clothing, razors, and so on with other family members. Wash the hands thoroughly after touching the skin lesions.
The sores of impetigo heal slowly and seldom scar. The cure rate is extremely high, but they often come back in young children.
The infection could spread to other parts of the body. This is common. Children often have multiple patches of impetigo. A systemic infection could lead to kidney failure (post-streptococcal glomerulonephritis). This is a rare occurrence. Permanent skin damage and scarring (also extremely rare). Prevention
Good general health and hygiene help to prevent infection. Minor abrasions or areas of damaged skin should be thoroughly cleansed with soap and clean water. A mild antibacterial agent may be applied if desired.
Impetigo is contagious, so avoid skin contact with drainage from impetigo lesions. Update Date: 4/15/2003
Synonyms and related keywords: impetigo contagiosa, group A beta-hemolytic streptococci, GABHS, Staphylococcus aureus, bullous impetigo, impetigo bullosa, common impetigo, folliculitis, follicular impetigo, ecthyma
Author: Randy Park, MD, Chair, Associate Professor, Department of Emergency Medicine, Denton Regional Medical Center
New Zealand Dermnet
Impetigo Fact Sheet
Community Health Administration - Maryland
Compendium of Images - Dermatlas
I have included cat scratch fever in the list of types of infections because of the number of cats people have as pets. Lymphedema patients ar particularly susceptible due to the localized immuno-deficiency of the lymphodemous limb.
Cat scratch fever is an infection that actually may be caused by either a virus or a bacteria. It results from either the bite or scratch of a cat that my otherwise look healthy. They are simply carriers of the virus/bacteria. The first signs are swelling and bumps filled with pus near the scratch. Lymph nodes in the neck, head and groin, o armpits begin swelling with two weeks. The symptoms can last for months.
What is cat scratch fever disease?
Cat-scratch Disease (lymphoreticulosis)
EVERYTHING, THAT YOU WANTED TO KNOW ABOUT CATSCRATCH DISEASE (lymphoreticulosis), lymphoreticulosis SYMPTOMS. EFFECTIVE TREATMENT OF CAT-SCRATCH DISEASE.
Extractions: Cat-scratch disease (benign lymphoreticulosis) Â– infectious disease associated with a history of scratches, bites from or close contact with a cat. The infecting agent is Bartonella henselae a tiny bacillus of familia Chlamydiae. The host and the source of infection are cats, with the infection agent being a normal part of their mouth flora. Person-to-person transmission of the disease has not been shown. The infection enters through skin wounds causing inflammation. Carried by lymph the infection reaches the nearest lymph node causing its inflammation too. Further the infection spreads with the bloodstream over the system. After convalescence the body develops persistent immunity to the disease. Treating cat-scratch disease (lymphoreticulosis). Symptoms of cat-scratch disease . Incubation period lasts from 3 to 20 days. A small, slightly elevated stain, slightly painful with a red rim appears in the place of the healed scratch or bite, turning in 2-3 days into a vesicle filled with a turbid content. The vesicle is then replaced by a small ulceration or crust. In several days after the scratch was inflicted the nearest lymph node gets enlarged. At this time the patient may complain of a headache, malaise, temperature. In some cases temperature may rise to 38-39 C and be associated with morning-night fluctuations and sweating, though in 7-10 days the temperature drops back to normal or slightly above. Sometimes the fever becomes tidal. Rarely high temperature may persist for 5-6 months and longer. Sometimes the disease progresses without temperature rise. The affected lymph node after reaching its maximum slowly diminishes, seldom purulent maturations end up with spontaneous opening and pus discharge.
Cat Scratch Disease
Synonyms and related keywords: CSD, cat-scratch disease, Parinaud oculoglandular disease, kitten scratch disease, la maladie des griffes du chat, benign inoculation lymphoreticulosis, benign inoculation reticulosis, catscratch fever, cat-scratch fever, regional granulomatous lymphadenitis
Author: Joseph R Lex, Jr, MD, Assistant Professor, Department of Emergency Medicine, Temple University Hospital
Cat Scratch Disease
Cat Scratch Disease
Cat Scratch Fever
TKH Bacteriology - Tara K. Harper
Localized pus filled infections. More commonly referred to as carbuncles, boils, folliculitis, and furnuncles.
Causes, Risk Factors Incidence
Skin abscesses are fairly common. They are caused when a localized infection causes pus and infected material to collect in the skin or subcutaneous tissue. Skin abscesses may follow a bacterial infection, commonly an infection with staphylococcus (staph aureus is most common). They can develop after a minor wound, injury, or as a complication of folliculitis or boils (furuncles, carbuncles). Skin abscesses may occur anywhere on the body. They affect people of all ages.
The abscess can obstruct and impinge on the functioning of deeper tissues. The infection may spread locally or systemically. The spread of infection through the bloodstream may cause severe complications.
Prevent and watch for bacterial infections. Keep the skin around minor wounds clean and dry. Consult the health care provider if you develop signs of infection, including fever, pain, redness, localized swelling, or drainage that looks like pus or is bloody. Treat superficial (minor) infections promptly.
skin lesion open sore or nodule reddened may drain fluid localized swelling, induration affected area is tender to touch Signs and Tests
The diagnosis is based on the appearance of the area.
Culture of drainage from the lesion may reveal the causative organism.
The goal of treatment is the cure of the infection.
Surgical incision and drainage of the abscess, with or without packing for 24 to 48 hours, cleans the area and allows infection to be controlled. Some skin abscesses may be drained in the health care provider's office.
Antibiotics are given to control the infection.
Heat (such as warm compresses) may speed healing, reduce inflammation, and reduce discomfort.
Elevate the affected part to reduce swelling and inflammation.
Most skin abscesses are curable with treatment.
localized spread of infection impingement on the functioning of adjacent structures gangrene (tissue death) systemic spread of infection causing: endocarditis osteomyelitis multiple new abscesses (“seeding” of infection) abscess formation on the joints, pleura, or other locations Call you doctor if
Call for an appointment with your health care provider if symptoms indicate skin abscess is present.
Also call for an appointment with your health care provider if new symptoms develop during or after treatment for skin abscess.
Necrotizing Subcutaneous Infections
Cutaneous Abscess Organism-Specific Therapy
Skin infection caused by staphlococcal bacteria. Appearance is characterised by red peeling skin. It is causd by the release of two toxins (epidermolytic toxins A and B) of from toxigenic strains of the bacteria Staphylococcus aureus.
Staphylococcal Scalded Skin Syndrome
Staphylococcal scalded skin syndrome
Staphylococcal Scalded Skin Syndrome
Last Updated: December 3, 2002
Author: Jessica Kim, MD, Staff Physician, Dermatology Service, Madigan Army Medical Center
Scalded skin syndrome
A Systematic Approach to Diagnosis and Treatment Part I: Cellulitis, Furunculosis, and Distal Finger Infections
Authors: Ramin R. Samadi, MD, FACEP, FACP, Chief Medical Officer, Tarrant Acute Care Physicians, PA, Fort Worth, TX; Medical Director, Trinity XpressMed Medical Center, Fort Worth, TX; and Assistant Clinical Professor, University of Texas Southwestern Medical School, Dallas; Gregory A. Volturo, MD, FACEP, Vice Chairman and Associate Professor, Department of Emergency Medicine, University of Massachusetts Medical School, Worcester.
Peer Reviewers: Larry B. Mellick, MD, MS, FAAP, FACEP, Vice Chairman for Academic Development and Research, Department of Emergency Medicine, Medical College of Georgia, Augusta; and Sandra M. Schneider, MD, Professor and Chair, Department of Emergency Medicine, University of Rochester School of Medicine, Rochester, NY.
This two-part series discusses bacterial skin and soft-tissue infections (SSTIs). Part 1 will discuss bacterial skin infections that quite frequently are encountered in the general practice of medicine and that predominantly are benign in nature. With proper diagnosis and treatment of these entities, no major complication or long-term sequellae should be expected. Part 2 will cover bacterial SSTI diseases that are less benign and more complicated, and/or occur less frequently and that, even with proper therapy, have the potential for severe complications and sequellae.– The Editor
Bacterial infections of the skin and underlying soft tissue encompass a wide variety of clinical entities and are common reasons for presentation to the emergency department (ED) or a primary care provider’s office. They range from simple pyodermas characterized by local induration, swelling erythema, warmth, and pain or tenderness that readily can be treated with local care and oral antibiotics, to more severe, life-threatening, necrotizing infections that are accompanied by systemic symptoms such as fever, chills, and, at times, hemodynamic instability, and require hospitalization and surgical intervention. SSTIs sometimes may become disseminated via the circulatory and lymphatic system, particularly in patients who are immune compromised. While many of these infections can be treated in the outpatient setting, moderate or severe cases may require hospitalization and parenteral antibiotic therapy. In 1995, it was estimated that more than 330,000 patients required hospitalization for SSTIs, with many more treated in the outpatient setting.1
A healthy normal stratum corneum layer of skin is a natural barrier to bacterial penetration. The exact mechanism of this resistant barrier is not fully understood, however many factors that are directly related to skin play a significant role in the provision of this first line of defense. These factors include the keratinized nature of the layer, skin’s natural acidity (pH: 5.5) and relative dryness, skin’s normal microflora, skin’s continuous desquamation and sloughing, and presence of antibacterial substances and intracellular lipids.2 Any derangement in any one of these factors can predispose the skin to a variety of infections. Damaged skin is susceptible to bacterial colonization, proliferation, and invasion. This phenomenon occurs even with a minor break in the stratum corneum layer. Once this layer is breached, rapid penetration of bacteria will result in dermal echthymatous lesions or deeper cellulitis. In a more extensive wound, the resultant build-up of serum will permit the growth of the pathogenic bacteria and the rapid replacement of the resident flora. Furthermore, an overall decline in the individual’s cellular or humeral immune system also will make the skin susceptible to infection.
Skin and Soft-Tissue Infections
Bacteriology of the SSTIs differs significantly based upon the depth and level of the infection (epidermal vs dermal vs soft-tissue) and the actual infected tissue (skin or soft tissue vs skin appendices).
Gram-positive bacteria cause the majority of the SSTIs. However, gram-negative organisms (primarily Pseudomonas aeruginosa) are occasionally the causative pathogens, particularly in the groin, ear, foot ulcers, and macerated interspace infections. Anaerobic organisms may play a significant role in the deep soft-tissue and necrotizing infections.
Staphylococcus aureus and Group A beta-hemolytic Streptococcus (GAS) are the primary pathogens involved in the primary and secondary SSTIs in outpatient settings.3 S. aureus commonly is found in the environment and on the skin; however, the normal bacterial flora act as the first line of defense. While S. aureus often invades the skin via hair follicles, Streptococci invade the skin through the breaks in the stratum corneum layer.
Methicillin-resistant Staphylococcus aureus (MRSA) has emerged as an important and common pathogen among hospitalized patients since the 1960s.4 According to estimates from the National Nosocomial Surveillance System of the Centers for Disease Control, the incidence of MRSA causing nosocomial infections in intensive care unit patients has approached 50%.5 Recent surveillance data suggest that almost 30% of S. aureus isolated from hospitalized patients with SSTIs is methicillin– resistant.6 Established risk factors for MRSA infections include: prolonged hospitalization or surgery, care in an intensive care unit, prolonged antimicrobial therapy, residence in a long-term care facility, dialysis, close proximity to a patient in the hospital who is infected or colonized with MRSA, and intravenous drug use.7 Recently, cases of MRSA infection have been reported in both rural and urban communities and in patients without traditional risk factors. Many cases of community-acquired MRSA (CAMRSA) have occurred in children and young adults who typically do not have the associated health care related risk factors. While some of these strains may have origins in the hospital, others appear to be novel and unrelated to known hospital strains.8 MRSA colonization can persist for months to years and the majority of patients remain asymptomatic. Therefore, the acquisition of MRSA, whether it occurs in the hospital or the community, often will go unrecognized unless clinical infection develops.9 In one study 84% of CAMRSA infections involved the skin and soft tissues (especially abscess and cellulitis), with invasive infections occurring only rarely and usually secondary to a primary SSTI.10,11 Patients with CAMRSA skin infections were more likely to have received a prescription for an antimicrobial agent in the 180 days preceding the infection than were the group of patients with methicillin-susceptible S. aureus skin infections.11
The CDC has reported several clusters of CAMRSA SSTIs involving participants in competitive sports in a variety of settings, including high school and college athletic teams, and even in participants in minimal contact sports such as fencing. Physical contact, skin damage, and sharing of equipment, clothing and other personal items that are not laundered between uses were identified as possible risk factors for infection. Sharing of balms and lubricants also may spread infection. Encouraging good hygiene among players and implementing a system to ensure adequate wound management, including covering skin lesions before play and routine cleansing of shared equipment, may assist in controlling the spread if infection.12 Physicians should be aware of the potential for CAMRSA infections in sports participants when evaluating patients and making treatment decisions. Recurrence of infection potentially may be avoided if cultures are obtained more routinely when athletes have infected wounds. CAMRSA infections also have been reported in both male and female correctional facilities and in men who have sex with men.10
Most CAMRSA isolates are susceptible to antibiotics other than beta-lactams, whereas most nosocomial isolates are resistant to antibiotics other than beta-lactams.4 The emergence of CAMRSA in otherwise healthy young individuals has significant implications in the management of SSTIs, as most SSTIs initially are managed with beta-lactam antibiotics. Inadequate empiric antimicrobial therapy may allow CAMRSA infections to progress, resulting in more serious infections and clinical complications. Obtaining cultures of infected sites is highly recommended when staphylococcal infection is suspected. Optimal treatment of CAMRSA disease should be based on the infecting organisms’ antimicrobial susceptibility when available. To prevent clinical complications, health care providers should consider modification of empiric antibiotic regimens in areas where CAMRSA infections are prevalent. Most of these isolates still are susceptible to multiple antimicrobial classes (including trimethoprim-sulfa-methoxazole, tetracyclines, and clindamycin), however many CAMRSA isolates are beginning to demonstrate resistance to fluoroquinolones.10 Treatment of CAMRSA infections should not routinely require the use of vancomycin.4
There has been considerable debate regarding the benefits, timing, and methods used to culture SSTIs. Culturing the skin in cases of cellulitis rarely yields a pathogen; however, obtaining a specimen for culture from other wounds for gram stain and culture frequently is useful, especially if the prevalence of MRSA in the community is high. Local antibiotic resistance patterns should be considered when deciding whether to obtain specimens for culture and sensitivity; the lower the prevalence of resistant stains, the less the need to culture.
In specific and clinical or epidemiological circumstances, a number of other infectious pathogens also may cause infections. (See Table 1.)
Diagnosis, Management and Classification. Bacterial SSTI must be differentiated from a wide range of non-bacterial or non-infectious skin and soft-tissue diseases and disorders. These diseases may include, but are not limited to, localized and systemic allergic reactions, viral exanthematous rashes, skin manifestation of systemic diseases, insect and marine animal bites and envenomations, parasitic infestations, and drug eruptions.
A successful diagnosis of SSTI depends on the appearance of the lesion; chronology of the process; patient’s age; medical history and the integrity of the immune system; evidence of systemic manifestation of infection; history of trauma or surgery; unusual travel; activity; and insect, animal, or human bite(s).
Optimal management of SSTIs begins with a physical examination and obtaining the complete medical and social history of the patient. SSTIs, however, can pose considerable diagnostic and therapeutic challenges. These infections can affect a wide variety of tissues and are caused by a variety of microorganisms. The clinical manifestations are wide ranging and host factors, which may contribute to the development of these infections, may not be readily apparent. Culturing the causative organism often is difficult and takes several days; hence, initial treatment regimens usually are empiric and targeted at the most common organisms.
Classification. For classification purposes, bacterial skin infections are divided into infections of skin appendices and infections of skin.
Infections of the Skin Appendices
The hair follicles and their supporting and surrounding structures frequently are infected skin appendices. S. aureus is the most common causative pathogen. These infections can be classified into the types that follow.
Folliculitis. Folliculitis is an inflammation of the hair follicle. It commonly occurs in areas of skin that are covered by coarse, short hair. Obstruction of the adjacent sebaceous gland is the primary cause of the infection. Friction is a common predisposing factor. Application of mineral-based oils is another predisposing factor. The majority of folliculitis cases are caused by S. aureus.13
Folliculitis is manifested by patches of 1-5 mm erythematous papules or pustules at the base of the hair follicle. It usually is non-tender; occasionally it can be pruritic or painful. Pustules have a dirty yellow or gray color. Manipulation of folliculitis may result in transient bacteremia. Gram-negative folliculitis, caused by organisms such as Klebsiella or Proteus, may occur in patients who have been on chronic antibiotic therapy.
Hot tub or spa pool folliculitis is caused by Pseudomonas aerugenosa. The organism proliferates in warm and moist environment, especially if the water has high pH (</ = 7/8) or is poorly chlorinated. It also may grow on exfoliative beauty aids (loofah or synthetic sponges). Even normal hosts with intact skin are affected. The resultant folliculitis occurs predominantly in the confined areas of the skin that are covered by the bathing suit and/or immersed in the water. Folliculitis usually is manifested within 6-120 hours post exposure. Papular lesions progress rapidly to pustules or vesicles and may be pruritic. Lesions also may occur in the auditory canal. Patients may experience low-grade fever, headache, dizziness, malaise, and sore throat. Most cases are mild and self-limiting.13-16
Treatment. Isolated Folliculitis. Use of warm compresses and gentle cleaning of the lesion(s) with topical benzol peroxide or an antibacterial soap should be a sufficient therapy. Use of topical antibiotics, such as mupirocin, erythromycin, or clindamycin also should be considered and may hasten recovery. Use of systemic antibiotic therapy is not required. With proper approach, the lesions usually resolve without any residual scarring.
Extensive or Refractory Folliculitis. Systemic anti-staphylococci antibiotic therapy should be added to the above-mentioned therapeutic modalities. First-generation cephalosporins (cephalexin 500 mg PO bid x 10 days) or azythromycin (500 mg, day 1 and 250 mg days 2-5, PO qd) are first-line antibiotic agents. Alternative antibiotics include moxifloxacin, ampicillin-clavulanate, dicloxacillin, erythromycin, or minocycline. In refractory cases, the presence of MRSA must be considered and ruled out.
Hot Tub Folliculitis. In most healthy patients, lesions resolve spontaneously, and scarring is rare. If treatment is necessary, it should include topical 0.1% polymyxin B. In adults with severe or refractory cases, oral ciprofloxacin (500 mg PO bid x 7-10 days) should be considered as the drug of choice. In children with severe infection, an anti-pseudomonas semi-synthetic penicillin should be utilized.
Furunculosis (Boil). Furunculosis is due to the extension of folliculitis into the surrounding subcutaneous tissue. Having one episode is a reliable predictor of future similar events. Recurrent furunculosis is a challenging problem in patients suffering from diabetes mellitus, atopic dermatitis, immune deficiency (congenital or acquired), alcoholism, obesity, or malnourishment and use of corticosteroids or cytotoxic agents. These patients may be colonized by S. aureus in their nares, or on their skin.
Furunculosis is manifested by an erythematous, deep-seated, painful nodule adjacent to a hair follicle. It can grow rapidly and become fluctuant. The lesion may rupture spontaneously into an ulcer. At times, it is complicated by bacteremia and possible hematogenous secondary seeding of heart valves, long bones and spine, joints, meninges, and viscera (especially kidneys).
Outbreaks of persistent furunculosis on the lower extremities have been reported in patrons of nail salons. The causative organism has been identified as Mycobacterium fortuitum. There usually is more than one lesion associated with risk factors such as use of whirlpool footbaths and shaving of the legs with razor before pedicure.
Several conditions can be mistaken as furunculosis. Other lesions and diseases such as hydradenitis suppurativa, herpes simplex infections, fire ant bites, kerions, and molluscum contagiosum must be considered as an alternative diagnosis and excluded. Obtaining a travel history also is very important. In a patient with recent travel to Mexico or Central or South America, the diagnosis of larva of botfly (Dermatobia hominis) must be excluded.17
Treatment. Simple Furunculosis. In most cases treatment consists of application of local heat. Incision and drainage is the treatment of choice and commonly is required. In most cases, systemic antibiotic therapy is not necessary.
Furunculosis with Surrounding Cellulitis or Systemic Signs. Incision and drainage is the treatment of choice. Use of a systemic antibiotic, such as first-generation cephalosporins (cephalexin 500 mg PO bid x 10 days) or azythromycin (500 mg, day 1 and 250 mg days 2-5, PO qd) usually is required. Other acceptable antibiotics are dicloxacillin, clindamycin, or erythromycin.
Recurrent Furunculosis. In this patient population, colonization of nares or skin by S. aureus should be evaluated and, if positive, treated. Therapeutic regimens include use of topical mupirocin ointment or cream every six hours for seven days. Furthermore, diabetes mellitus must be ruled out. Addition of systemic oral antibiotics such as clindamycin (150 mg PO qd x 3-months) (best results), rifampin (600 mg PO qd x 7-10 days), or cloxacillin (500 mg q 6 hours x 7-10 days), also should be considered.18,19
Carbuncle. Carbuncle is the result of confluence of several furuncles and further lateral extension of the infectious process into the surrounding soft tissue. It usually is secondary to manipulation or neglect of the initial furunculosis. It will result in the destruction of the normal fibrous tissue walls and formation of tunnel-like, interconnected sinus tracts and abscesses.13
Carbuncle is manifested as a large, erythematous, deep-seated, and very painful lesion. Systemic signs such as fever, chills, malaise, and lymphadenopathy usually are present. Its complications may include cellulitis, septicemia, thrombophlebitis, and secondary bacterial seeding(s).
Treatment. The main therapeutic approach is through incision and drainage of the abscesses. Oral or parenteral systemic anti-staphylococci antibiotics also should be administered. Choices of antibiotic therapy are the same as for furunculosis. Careful exploration of the lesion with a blunt object ( i.e., a hemostat) may be necessary to break up any loculated abscess.
Infections of the Skin
Impetigo Contagiosa. Impetigo is a superficial indolent infection of the skin.20 It is the most common skin infection in children. The causative pathogens include group A beta-hemolytic Streptococcus (GAS) and S. aureus. Co-infection by both bacteria also is common. Impetigo easily can be spread from person to person. Due to predilection for a warm, moist environment, late summer and early fall are the peak seasons for the occurrence of this disease.
Impetigo initially is manifested as scattered, discrete, small papules. These lesions will transform into pustules and vesicles. Rupture of these pustules or vesicles will result in the impetigo’s 1.0-3.0 cm characteristic golden-yellow, stuck-on crusts. These lesions have an erythematous and inflammatory base. Lesions can be pruritic and occur predominantly on the face and near the mouth and nose. Lesions also may occur at the site of minor trauma. Satellite lesions are fairly common. Regional lymphadenopathy may be present. Rare complications include glomerulonephritis.
Bullous impetigo is a variant of this disease. It presents as a large flaccid bullae filled with a yellow liquid. Following the rupture of the bullae, lesions with a scalded nature appear. The surrounding skin has a superficial erosive pattern. The causative Phage II S. aureus produces the extracellular exfoliating exotoxin.21
In refractory or more severe and widespread cases, systemic oral antibiotics such as amoxicillin-clavulanate or cephalosporins for S. au-reus should be prescribed. Advanced-generation cephalsporins (e.g., cefdinir) are resistant to beta-lactamase and maybe a better therapeutic choice. Alternative agents include dicloxacillin or erythromycin.
Ecthyma (Ulcerative Impetigo). Ecthyma is an ulcerative infection of the skin, caused most commonly by group A beta-hemolytic Streptococcus or S. aureus. It can affect patients of all ages and usually is seen in crowded living conditions. It is associated with poor hygiene, heat, humidity, and poor nutritional status. Occasionally Pseudomonas aeruginosa also can be the causative bacteria. Skin lesions caused by P. aeruginosa usually are metastatic seeding of a septicemia and are called ecthyma gangrenosum.
Ecthyma is manifested as superficial, punched-out, ulcerative lesions associated with adherent necrotic crust and raised inflammatory borders. Occasionally it may present as a vesicle or pustule. Lesions may be painful or pruritic. Lower extremities mostly are affected. Lesions often occur at the site of minor trauma. The lesions are slow to heal and often result in scarring.
Treatment. Debridement of the necrotic tissue and incision and drainage of the fluctuant vesicles and pustules must be performed. Systemic oral anti-staphylococcus antibiotic also must be administered. Choices of antibiotic agents are the same as the treatment of impetigo contagiosa.
Erythrasma. Erythrasma is a chronic bacterial infection of the intertriginous areas of toes, groins, sub-mammary, gluteal and axilla. It predominantly affects overweight adults. Diabetes mellitus is a predisposing factor. Corynebacterium minutissimum is the causative pathogen.
Erythrasma is manifested as erythematous macular lesions covered with fine scaling on a sharply marginated background. The lesions can be scattered or confluent patches. It can be misdiagnosed as Tinea cruris.
Treatment. Econazole cream, which has both antifungal and antibacterial activity, can be used topically. Topical antibiotics are not effective. In extensive cases, systemic oral antibiotics such as macrolides (e.g., erythromycin 250 mg every 6 hours for 14 days) can be used.
Cellulitis. Cellulitis is an acute deep infection of the skin involving the dermis and subcutaneous tissue. Bacteria usually gain access to the epidermis through skin cracks or following minor trauma or burns; however, an entry portal may not be evident. Risk factors include diabetes mellitus, hematological malignancies, IV drug abuse, chronic lymphedema, and immunocompromise.
Bacteriology and Epidemiology. Cellulitis caused by S. aureus spreads centripetally from a localized source of infection such as furunculosis. In contrast, cellulitis due to Streptococcus pyogenes is a more rapidly spreading, diffuse process and usually is associated with fever and lymphangitis. (See Table 2.)
Recurrent Streptococcal cellulitis of the lower extremities may be caused by group A, C, or G Streptococci in association with chronic venous stasis, saphenous venectomy for cardiac bypass surgery (CABG), or chronic lymphedema secondary to lymph node dissection, elephantiasis, or Milroy’s disease. Recurrent S. aureus cellulitis is more common in individuals who have eosinophilia and elevated serum levels of IgE (Job’s syndrome) and among nasal carriers of the bacteria.
Group B streptococcus (GBS) is the causative pathogen for cellulitis in newborns.
Cellulitis caused by Streptococcus agalactiae is seen frequently in patients with diabetes mellitus or peripheral vascular disease.
Haemophilus influenzae is the causative pathogen for periorbital, head, and neck cellulitis in children who are suffering from sinusitis, otitis media, or epiglottitis. Most patients are younger than 3 years of age.
Pseudomonas aeruginosa cellulitis frequently follows penetrating injuries, i.e., sweaty tennis shoe syndrome. Bacteria are introduced into the deep tissues by stepping on a nail. In a neutropenic patient, P. aeruginosa infections also can present as ecthyma gangrenosum. These lesions usually occur on the extremities and rapidly become necrotic and ulcerative.
Aeromonas hydrophilia causes very aggressive cellulitis in tissues surrounding lacerations sustained in freshwater lakes, rivers, and streams.
Erysipelothrix rhusiopathiae cellulitis occurs predominantly in bone renderers and fishermen.
Vibrio vulnificus cellulitis occurs predominantly on the extremities following exposure to sea water.
Mycobacterium marinum may cause cellulitis in patients who are exposed to aquariums or are injured in a swimming pool.
Presentation. Systemic signs, fever, chills, anorexia, or malaise may develop rapidly. High fever usually is associated with streptococcal infections. Lesions present as edematous, erythematous, hot plaques of severe tenderness of various sizes. The borders usually are irregular and elevated but sharply defined. Lesions may proceed to vesicles, bullae, erosions, abscesses, hemorrhage, and necrosis. Among other bacteria, H. influenzae and pneumococcal cellulitis may cause a bluish-purple discoloration of the involved skin.
Diagnosis. Diagnosis primarily is made clinically. Isolation of the etiologic pathogen often is difficult. In most cases the causative pathogen can be suspected based upon the epidemiologic data. Unless there is drainage or an open wound, even with the aspiration of the leading edge or punch biopsy, cultures are positive in fewer than 25% of cases. Nevertheless, cultures should be obtained in severely ill or immunocompromised patients.22
Treatment. Uncomplicated Cellulitis. Systemic oral anti-staphylococcal antibiotics should be administered. In adults, acceptable first-line antibiotics may include first-generation or advanced-generation cephalosporins, amoxicillin-calvulanate, clindamycin, advanced flouroquinolones, erythromycin, and dicloxacillin. Considering the ease and frequency of administration and the resultant higher level of patient compliance with therapy, azythromycin (500 mg day 1 and 250 mg days 2-5 PO qd) or moxifloxacin (400 mg PO qd x 7 days) may be considered better therapeutic agents. Similarly, in children, azythromycin, amoxicillin-clavulanate, first- and second-generation of cephalosporins, clindamycin, and dicloxacillin are drugs of choice.
Cellulitis Associated with Diabetes Mellitus or Pressure Ulcers. Broad spectrum systemic parentral antibiotics to provide coverage for gram-positive, gram-negative, and anaerobic bacteria must be started. Antibiotics of choice include fluoroquinolones (ciprofloxacin 500 mg PO bid x 14 days), advanced-generation cephalosporins, ampicillin-sulbactam, ticarcillin-clavulanate, or aminoglycosides plus clindamycin.
Pathogen-specific Antibiotic Therapy. Pseudomonas aeruginosa. Drugs of choice include anti-pseudomonas third-generation cephalosporins (ceftazidime, cefoperazone, or cefotaxime), anti-pseudomonas semi-synthetic penicillins (ticarcillin, mez-locillin, or pipracillin), or fluoroquinolones. In cellulitis associated with penetrating injuries involving deep tissue, bones, or joints, surgical inspection and drainage must accompany antibiotic therapy.
Aeromonas Hydrophilia. This bacteria is resistant to ampicillin. Drugs of choice include aminoglycosides, advanced fluoroquinolones, chloramphenicol, trimethoprim-sulfamethoxazole, or advanced-generation cephalosporins.
Cellulitis of Specific Areas
Erysipelas. Erysipelas is a superficial skin infection that is associated with lymphatic involvement. It is most exclusively caused by Streptococcus pyogenes.23 On occasions, other pathogens such as non-group A Streptococci (B, C, or G), H. influenza, S. aureus, and Streptococcus pneumoniae (rare) also may be the culprit.24 It is more common in children and the elderly. The predisposing factors include diabetes mellitus, venous stasis, alcoholism, and chronic lymphatic obstruction and lymphedema. It is fairly common in patients with radical mastectomy and post-operation chest wall radiation therapy. One-third of cases have a recurrent pattern. Patients with either venous or lymphatic stasis are more prone to recurrence. Repeated infections also may cause impairment of lymphatic drainage. In neonates, infection may occur in the umbilical cord stump and spread rapidly over the abdomen.
Presentation. Erysipelas presents with a rapidly expanding, intensely erythematous, edematous, firm, tender, and painful plaque. The borders are well defined and there is no central clearing. The size of the plaque is variable. The common sites for lesions are the face (close to the nares or ears) and the lower extremities. The infections of lower extremities now are more common than the facial infections. Fever, chills, diaphoresis, anorexia, vomiting and other systemic signs are fairly common. Regional lymphadenopathies usually are present. Flaccid bullae may appear during the second or third days of presentation. Lesions rapidly may progress to lymphangitis, cellulitis, abscess, or faciitis.25 Less acute cases may occur at the leg stasis ulcer sites.
Diagnosis. In most cases the diagnosis is made based on clinical appearance. Cultures rarely are useful.
Treatment. Treatment with a parenteral systemic antibiotic must be initiated immediately. After 4-5 days, antibiotic therapy can be switched to an oral form. The treatment of choice is benzyl penicillin followed by penicillin VK for a total of 10-14 days. Other antibiotic agents include dicloxacillin, nafcillin, first-generation cephalosporins, cefuraxime, and erythromycin. In diabetic patients or in those with facial involvement, the clinician should consider the possibility of infection with beta-lactamase producing organisms. In these cases, use of amoxicillin-clavulanate or advanced-generation cephalosporins is a necessity.
Pyoderma. Pyoderma is due to the secondary infection of a pre-existing skin lesion. Primary lesions include stasis ulcers of lower extremities, eczema, or exfoliative skin disease. The causative pathogen is predominantly P. aeruginosa. The infectious process can be aggressive, rapidly progressing, and invasive or may follow a more indolent course. The acute cases present in a moth-eaten pattern surrounded by a raised erythematous border. The chronic cases are manifested as a slowly growing and burrow-forming lesions. Subsequently, these lesions become papulovesicular crops and are covered with a malodorous crust.
Diagnosis. Causative bacteria readily may be cultured from both the acute and chronic lesions.
Treatment. Systemic oral anti-pseudomonas antibiotics should be administered. The drug of choice is ciprofloxacin.
Cellulitis Around the Eye
Cellulitis around the eye is a potentially dangerous process. An intact orbital septum prevents the progression of the inflammatory processes of the eyelids to expand posteriorly. Periorbital cellulitis must be differentiated from orbital cellilitis. CT scans can be a very useful tool in the differentiation process.
Periorbital Cellulitis. Periorbital cellulitis is an acute inflammatory process that is limited to the eyelids. It is more common in children and usually is subsequent to upper respiratory tract infections. Eye or orbit trauma may act as a predisposing factor. Systemic manifestations, such as fever, also may be present. Patients may develop conjunctivitis, too. Cellulitis predominantly is caused by S. aureus and Streptococcus pyogenes in adults and H. influenzae in children. The clinician should consider the significant overall reduction of H. influenza infections in the United States and other advanced countries secondary to the widespread use of the HIB vaccine. Periorbital cellulitis rarely is associated with central nervous system (CNS) complication.
Treatment. Adults without any systemic manifestation may be treated with warm soaks and systemic oral anti-staphylococci antibiotics. Young children should be treated more aggressively with a systemic parenteral antibiotic. Advanced-generation cephalosporins, i.e., ceftriaxone, are the antibiotic of choice.
Orbital Cellulitis. Orbital cellulitis is a true emergency. The infection predominantly is secondary to acute sinusitis. The infection spreads either by direct extension or in a retrograde pattern through the facial veins. S. aureus is the main pathogen in adults and H. influenzae infections are most common in children. Blood cultures are positive in up to 60% of pediatric cases. The cellulitis is associated with proptosis, chemosis, orbital pain, and restriction of eye movements. Visual disturbances occur in more than half of patients. Abscess formation is a common complication and should be ruled out by a CT scan of the orbit. Other complications include permanent blindness, ophthalmoplegia, and diplopia. Meningitis, cavernous sinus thrombosis, and brain abscesses are other rare complications.
Treatment. Systemic intravenous antibiotic therapy should be initiated immediately. Ceftriaxone is the drug of choice. It penetrates the CNS very well and is very effective against H. influenzae.
Cellulitis Around the Anus
Perianal Cellulitis. Perianal cellulitis occurs more frequently in children than adults, and boys are affected more often than girls. The children are not appear to suffer from systemic illness. It may be associated with pharyngitis. Streptococcus pyogenes is the most common pathogen. Cellulitis presents as bright erythematous perianal patches extending from the anal verge. It often is associated with painful defecation, anal pruritis, blood streaking of the stool, and anal tenderness. This bacterial infection commonly is misdiagnosed as Candidiasis. Correct diagnosis may require obtaining a culture. Recurrence is frequent.
Treatment. Topical antibiotics are useful; however, addition of a systemic oral antibiotic therapy is indicated in most cases. Drugs of choice include penicillin or erythromycin. Therapy should be continued for 10-14 days.
Infections of Distal Fingers and Toes
Paronychia. Paronychia is a superficial cellulitis or abscess of the paronychial (nail fold) tissues of the hands and feet. Any disruption of the area between the nail bed and nail fold can act as a port of entry for the pathogenic organism. This disruption may be secondary to a minor trauma following nail bed manipulation or spontaneous. Paronychia is one of the most common infections of the hand. The infectious process may proceed either in an acute or chronic mode. Paronychia also may be secondary to non-infectious causes, i.e., chemical irritants and chronic excessive moisture.
Acute Paronychia. Acute paronychia presents with a rapid onset of localized erythematous, tender, and edematous lesions of the lateral and proximal nail folds. A pustular lesion may develop within few days. Pus may penetrate into the nail bed and cause either discoloration and/or elevation of the nail from the underlying matrix. If the infection remains untreated, an abscess also may develop. Drainage of the abscess should result in the abrupt relief of pain. Persistence of pain should suggest a deeper infectious process. If the abscess is left unattended, the pus may spread to the opposite side and cause a run-around abscess.
Acute paronychia commonly are encountered in patients who suck their fingers, bite their nails, have hang nails, or have penetrating trauma. Aggressive manicuring and artificial sculptured nails also may predispose the patient to this infection.
The most common pathogenic organisms are S. aureus, in majority of cases, and Streptococci species. In rare occasions, specifically in nail-biting or finger-sucking children, infection may be due to the bacteria that are considered as normal mouth flora. These specific pathogens are the same organisms that cause wound infections following human bites. (This will be discussed in detail in Part 2 of this article).
On occasion, P. aeruginosa also may cause a form of acute paronychia. These causes usually are a secondary bacterial infection and follow a primary dermatophytes infection of the nails or a minor trauma to the distal phalanx. The involved skin appears as a pinkish-white in color, associated with moderate to severe pain and edema. Lesions have a tendency to become ulcerative and macerated. P. aeruginosa also may cause the green nail syndrome. Subsequent to the development of paronychia, and due to pyocyanin pigment, the adjacent nail becomes develops a greenish discoloration. Even with proper treatment, this benign discoloration may last for months.
Treatment. Conservative therapy, such as warm soaks and possibly topical antiobiotics, may be effective in the early phase of acute paronychia. A more advanced infection or the development of an abscess will necessitate the use of oral anti-staphylococcal antibiotic agents. The drugs of choice include amoxicillin-clavulanate or clindamycin. The frequently encountered resistance patterns associated with S. aureus should negate the use of antibiotics such as penicillin, ampicillin, or first-generation cephalosporins.
With the development of an abscess, an incision and drainage procedure will be required. In more advanced stages, the removal of the involved nail may be necessary.
Paronychia caused by P. aeruginosa should be treated with topical dilute acetic acid (0.25-1.0%) or polymyxin B (0.1%).
Chronic Paronychia. Chronic paronychia is rare following the acute disease. It is more common in individuals whose hands are chronically moist. Manipulation of the nail cuticles also can predispose the individual to this disease. Most commonly, all fingernails are affected simultaneously. The infection is insidious and presents with separation of the cuticle, tenderness, and edema of the proximal and lateral nail folds. Occasionally a small amount of pus can be expressed from under the nail fold. Although a brownish discoloration of the nail may occur, the nail plate is not affected and remains intact. Lack of subungual thickening will differentiate chronic paronychia from fungal infections. This infection can be due to gram-positive or gram-negative organisms or Candida.
Treatment. Avoidance of the predisposing factors plays a significant role in treatment of chronic paronychia. Systemic oral antibiotics or antifungal medications do not effectively penetrate the infectious site and generally are ineffective. Treatment with a combination of topical steroids and antifungal agents have proven to be successful. Other treatment modalities may include application of topical 3% tymol in 70% ethanol drops. Addition of fluconazole to this regimen also may improve the therapeutic outcome and control the recurrence. Other therapeutic options may include use of topical antibiotics or acetic acid soaks (1:1 ratio of vinegar to water). Excellent responses have been reported with eponychial marsupialization technique or complete removal of the infected nails, followed by the application of the above-mentioned topical treatments.
Felon. Felon is a serious infection that involves the pulp of the distal phalanx of a finger. It usually is secondary to a minor injury, a localized wound, or extension of a localized superficial infection. Infection is manifested as a severely painful, erythematous, hot, and edematous area involving the palmar aspect of the distal phalanx. S. aureus and Streptococcus pyogenes are the most common pathogens. Gram-negative organisms also occasionally have been implemented. If neglected, undiagnosed, or untreated, it commonly is complicated with abscess formation and loss of tissue. In these situations, secondary loss of function is a very common occurrence.
Treatment. Surgical intervention remains the first line of therapy. Systemic intravenous anti-staphylococci antibiotics also should be administered promptly.
Tice A, Poretz D, Cook F, et al. Medicare coverage of outpatient ambulatory intravenous antibiotic therapy: A program that pays for itself. Clin Infect Dis 1998;27:1415-1421. Bonomo RA, Bradley SF, et al. Update on changing antibiotic susceptibility patterns: Topical antibiotic therapy. Proceedings from a Clinical Roundtable. Cutis 2003;71:4-24. Leyden JJ, Stewart R, Klingman AM. Experimental infections with group A streptococci in humans. J Invest Dermatol 1980;196-201. Naimi Y, LeDell K, Boxrud D, et al. Epidemiology and Clonality of Community Acquired Methicillin Resistant Staphylococcus aureus in Minnesota, 1996-1998. CID 2001;33: 990-996. National Nosocomial Infection Surveillance (NNIS) System. NNIS System report, data from January 1990-May 1999, issued June 1999. Am J Infect Control 1999;27:520-532. Rennie RP, Jones RN, Mutnick AH. SENTRY Program Study Group (North America). Occurrence and antimicrobial susceptibility patterns of pathogens isolated from skin and soft tissue infections: Report from the SENTRY Antimicrobial Surveillance Program (United States and Canada, 2000). Diagn Microbiol Infect Dis 2003 45:287-293. Eady E, Cove J. Staphylococcal resistance revisited: Community acquired methicillin resistant Staphylococcus aureus: An emerging problem for the management of skin and soft tissue infections. Curr Opin Infect Dis 2003;16:103-124. Eguia JM, Chambers HF. Community acquired methicillin-resistant Staphylococcus aureus epidemiology and potential virulence factors. Curr Infect Dis Rep 2003 5(6):459-466. Salgado C, Farr B, Calfee D. Community-acquired methicillin-resistant Staphylococcus aureus: A meta analysis of prevalence and risk factors. CID 2003:36:131-139. Centers for Disease Control and Prevention. Public health dispatch: outbreaks of community-associated methicillin-resistant Staphylococcus aureus skin infections–Los Angeles County, California, 2002-2003. JAMA 2003;289:1377. Baggett HC, Hennessy TW, Leman R, et al. An outbreak of community-onset methicillin-resistant Staphylococcus aureus skin infections in southwestern Alaska. Infect Control Hosp Epidemiol 2003 24:397-402. Centers for Disease Control and Prevention (CDC). Methicillin-resistant Staphylococcus aureus infections among competitive sports participants–Colorado, Indiana, Pennsylvania, and Los Angeles County, 2000-2003. MMWR Morb Mortal Wkly Rep 2003;52:793-795. Eiland G, Ridley D. Dermatological problems in the athlete. J Orthoped Sports Phys Ther 1996;23:388-402. Sadick NS. Current aspects of bacterial infections of skin. Derm Clin 1997;15:341-349. Kitamura M, Kawai S, Horio T. Pseudomonas aeruginosa folliculitis: A sporadic case from use of a contaminated sponge. Br J Derm 1998;139:359-360. Agger WA, Mardan A. Pseudomonas aeruginosa infections of intact skin. Clin Infect Dis 1995;20:312-308. Gewirtzman A, Rabinovitz H. Botfly infestation (myiasis) masquerading as furunculosis. Cutis 1999;63:71-72. Hedstrom SA. Treatment and prevention of recurrent staphylococcal furunculosis: Clinical and bacteriological follow-up. Scan J Infect Dis 1985;55-58. Wheat LG, Kohler RB, Luft FC, et al. Long term studies of the effect of rifampin on nasal carriage of coagulase-positive staphylococci. Rev Infect Dis 1983;5:S459-S462. Blumer JL, Lemon E, Snodgrass DJ. Changing therapy for skin and soft tissue infections in children: Have we come full circle? Pediatr Dis J 1987;6:117-122. Carson SC, Prose NS, Berg D. Infectious disorders of the skin. Clin Plast Surg 1993;20:67-76. Aly AA, Roberts NM, Seipo KS, et al. Case survey of management of cellulitis in a tertiary teaching hospital. Med J Aust 1996;165:553-556. Feingold DS, Hirschmann JV, Leyden JJ. Bacterial infections of skin. J Am Acad Derm 1989;20:469-475. Finch R. Skin and soft tissue infections. Lancet 1988;1: 164-168. Ramage L, Green K, Pyskir D, et al. An outbreak of fatal nosocomial infections due to group A streptococcus on a medical ward. Infect Cont Hops Epidemiol 1996;17:429-431. Visit this incredible website
Acta Dermatovenerol Alp Panonica Adriat. 2009 Jun
Pereira de Godoy JM, Azoubel LM, Guerreiro Godoy Mde F. Department of Medical School in São José do Rio Preto-FAMERP, Godoy Clinic in São José do Rio Preto-Brazil, Rua Floriano Peixoto, 2950, São José do Rio Preto-SP, 15020-010. firstname.lastname@example.org
AIM: The aim of this study was to evaluate the prevalence of erysipelas and lymphangitis in a group of patients under treatment for lymphedema after breast-cancer therapy.
METHODS: A random observational prospective study of the incidences of lymphangitis and erysipelas was performed for 66 patients with arm lymphedema after breast-cancer treatment. The study was carried out between March 2006 and December 2007 at the Godoy Clinic in Sãoo José do Rio Preto, Brazil. The clinical evaluation of the participants was performed weekly before the start of treatment, with patients being required to immediately report any complications to the attending service.
RESULTS: The mean time of follow-up of the patients between their treatment for breast cancer and the start of this study was 12.3 months, and three complications (4.5%) occurred; two cases of lymphangitis were reported after insect bites and one case of erysipelas after a hand injury, with repeat episodes reported by all three patients.
CONCLUSION: In spite of prophylactic advice regarding lymphangitis and erysipelas during treatment for lymphedema after breast-cancer therapy, patients are subject to complications; however, this in itself does not justify the use of prophylactic antibiotic therapy.
Rev Med Interne. 2002 Jun
Vaillant L, Gironet N. Service de dermatologie et unité de lymphologie, hôpital Trousseau, CHRU, 37044 Tours, France. email@example.com
Erysipelas and lymphangitis are frequent complications of lymphedemas (20 to 30%). The most important risk factor for erysipelas is lymphedema since this is a protein rich edema that contributes to the risk of infection. In case of lymphedema the treatment is the usual consensus treatment for erysipelas. A prophylactic treatment with penicillin is requested as soon as the first recurrence. This prophylactic treatment includes skin care, particularly treatment of injuries and intertrigos. Hyperplastic skin leads to maceration and then mycoses. Physiotherapy does not increase the risk for infection. Moreover an infection needs a complex decongestive physiotherapy which decreases risks of recurrence.
A case of streptococcal toxic shock syndrome due to Group G streptococci identified as Streptococcus dysgalactiae subsp. equisimilis.
Nei T, Akutsu K, Shima A, Tsuboi I, Suzuki H, Yamamoto T, Tanaka K, Shinoyama A, Kojima Y, Washio Y, Okawa S, Sonobe K, Norose Y, Saito R.
Division of Intensive Care Unit and Cardiac Care Unit, Nippon Medical School, Tokyo, Japan, firstname.lastname@example.org.
Abstract A 79-year-old man with a 3-month history of lymphedema of the lower limbs, and diabetes mellitus, was admitted to our hospital for suspected deep venous thrombosis. Several hours after admission, leg pain and purpura-like skin color appeared. On the 2nd hospital day, he was referred to our department for possible acute occlusive peripheral artery disease (PAD) and skin necrosis with blisters; however, computed tomography with contrast showed no occlusive lesions. He had already developed shock and necrotizing deep soft-tissue infections of the left lower leg. Laboratory findings revealed renal dysfunction and coagulation system collapse. Soon after PAD was ruled out, clinical findings suggested necrotizing deep soft-tissue infections, shock state, disseminated intravascular coagulation, and multiple organ failure. These symptoms led to a high suspicion of the well-recognized streptococcal toxic shock syndrome (STSS). With a high suspicion of STSS, we detected Group G β-hemolytic streptococci (GGS) from samples aspirated from the leg bullae, and the species was identified as Streptococcus dysgalactiae subsp. equisimilis (SDSE) by 16S-ribosomal RNA sequencing. However, unfortunately, surgical debridement was impossible due to the broad area of skin change. Despite adequate antimicrobial therapy and intensive care, the patient died on the 3rd hospital day. The M-protein gene (emm) typing of the isolated SDSE was revealed to be stG6792. This type of SDSE is the most frequent cause of STSS due to GGS in Japan. We consider it to be crucial to rapidly distinguish STSS from acute occlusive PAD to achieve life-saving interventions in patients with severe soft-tissue infections.
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