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lower-extremity_lymphedema_in_a_patient_with_gynecologic_cancer

Lower-Extremity Lymphedema in a Patient With Gynecologic Cancer

Kathleen Appollo, RN, BSN, OCN

Oncology Nursing Forum – Vol 34, No. 5, 2006

Case Study

H.F. is a 56-year-old woman who presented to the gynecologic oncology department at a major comprehensive cancer center after an endometrial biopsy revealed an International Federation of Gynecology and Obstetrics grade III serous carcinoma of the endometri- um. In addition to relevant endometrial cancer statistics, she received information about choices for treatment. The standard surgical treatment at the cancer center consists of a total abdominal hysterectomy with bilateral salpingo-oophorectomy, pelvic lymph node dissection, and para-aortic lymph node sampling. The acute and chronic side effects of surgery were discussed, including develop- ment of lower-extremity lymphedema. H.F. was informed that the lymphedema could occur anytime after surgery and she would need to monitor for lymphedema development for the rest of her life.

After preoperative testing, H.F. had an uneventful surgical procedure and routine postoperative course. The final pathology showed high-grade stage IIIC papillary serous carcinoma deeply invading the endometrium, with spread to a left para-aortic lymph node. As result, her oncologist recommended both radiation and chemotherapy.

H.F. completed all therapy and was scheduled to return every three months for evaluation. She was cautioned to maintain skin integrity by applying moisturizers and sunscreen as needed and to avoid sources of trauma, injury, infection, and constriction to the lower extremities. In addition, she was encouraged to maintain her weight with a healthy diet and she was advised to return to the lymphedema specialist for lymphedema control.

She understands that she must be diligent in her care to maintain control. H.F. knows that she should be joyous that she is free from cancer but often wonders about the sacrifices that she has made in the quality of her per- sonal life. She did not feel the need to seek professional psychiatric help but did join a support group. Although the members of the group all have cancer, none has lymphedema.

Even so, H.F. has found that sharing difficulties with others has helped her to cope, and she feels good when she has helped another deal with a difficult issue. Although she has not returned to her former music activities, she has found that helping others in the support group has given her the same satisfaction that she felt when her music brought happiness to others.

Lymphatic System and Lymphedema

Lymph is extracellular fluid composed of water, fats, proteins, bacteria, and waste products. The lymphatic system is an inter connected network of organs, lymph vessels, and lymph nodes that transports lymph from body tissues to the bloodstream, helping to maintain body fluid balance. It also is a major component of the body’s immune system.

The superficial lymphatic capillaries are made up of endothelial cells that overlap but do not form a continuous connection. Each cell is anchored to surrounding tissue by filaments that pull on the cells in response to changes in tissue pressure. As the cell is pulled by the filament, fluid drains into the vessel. Pressure changes occur during muscle contraction, respiration, and arterial pulsation and when the skin is stretched. Lymph flows into progressively larger deep vessels that have one-way valves to ensure that the fluid moves away from tissues in a slow, steady, low-pressure system. Afferent vessels carry lymph into lymph nodes, where the lymph is filtered of cellular waste products, pathogens, and cancer cells and where lymphocytes are added.

Efferent vessels carry lymph out of the lymph nodes to return to circulation. Lymph drains from the lower limbs into the lumbar lymphatic trunk, joining the intestinal lymphatic trunk and cisterna chyli to form the thoracic duct that empties lymph into the left subclavian vein (Casely-Smith & Casely-Smith, 1997; Mortimer, 1998).

Lymphedema occurs when lymph remains in the tissues because the lymphatic system is unable to transport interstitial filtrate (Foldi, 1998; International Society of Lymphology, 2003). Primary lymphedema is a result of an absence of or abnormalities in lymphatic tissue. Secondary lymphedema, which is the focus of this discussion, results when the flow of lymph is interrupted because of malignancies, surgery, infection, trauma, or postradiation fibrosis and the lymph remains in the tissue.

Incidence and Risk Factors

Although much has been written about upper-extremity lymphedema after breast surgery, information about lower-extremity lymphedema is lacking. The literature varies widely about the number of patients affected. In one study, the incidence of lymphedema in patients after a hysterectomy with lymph node removal was 20% (Ryan, Stainton, Slaytor, et al., 2003). Another study reported a 3.4% incidence rate in patients following endometrial staging surgery, including hysterectomy, bilateral salpingo-oophorectomy, and lymph node dissection (Abu-Rustum et al., 2006). A retrospective series of staging surgery for endometrial cancer followed by radiation therapy reported an incidence of 4.6% (Nunns, Williamson, Swaney, & Davy 2000).

H.F. was at risk to develop lymphedema after her surgery for endometrial cancer because of the disruption of lymphatics and lymph nodes during staging surgery. She was at additional risk because of the postoperative radiation. Other risk factors are believed to include injury, trauma, heat changes, infection to the extremity, and weight gain and decreased mobility (Brewer, Hahn, Rohrbach, Bell, & Baddour, 2000; Mortimer, 1998).

Treatment

Although research is lacking to support many recommendations for the prevention of lymphedema (Ridner, 2002), education regarding measures that are believed to reduce risk include protecting the skin from trauma and infection. Those measures were discussed with H.F. postoperatively and at each office visit. The plan is based on the concept that any action or condition that predisposes a patient to or increases swelling may disrupt the fine balance of drainage after surgery (Mortimer, 1998). In addition, open skin may lead to infection, which can occur more easily in stagnant, protein-rich lymph fluid, a perfect medium for bacteria growth (Brewer et al., 2000). Because deep vein thrombosis and cancer recurrence can cause swelling, they were ruled out before H.F. was referred for complex decongestive therapy. Her treatment began with manual lymphatic drainage, a gentle massage that starts proximally to encourage the flow of lymph from the distal extremity. More lymph is encouraged to move into the normally functioning lymphatics (Cheville et al., 2003; Foldi, 1998; Lerner, 1998).

Massage was followed by padding of the extremity and application of short stretch compression bandages with gradual pressure changes distally to proximally. That type of bandaging helps the flow of lymph to the nodal basins (Cheville et al.; International Society of Lymphology, 2003).

H.F. was taught the techniques so that she could continue maintenance therapy at home. She was encouraged to practice manual lymphatic drainage, use compression bandages at night, wear a fitted compression garment, follow meticulous skin care guidelines, protect the leg from trauma and injury, and perform muscle-building exercises. H.F. also was taught to wear the compression garment especially during air travel because changes in atmospheric pressure may increase the pressure balance in the leg (National Lymphedema Network, 2005).

Quality of Life

Lymphedema may have a profound effect on the lives of cancer survivors (Kwan et al., 2002; Ryan, Stainton, Jaconelli, et al., 2003). H.F. described a heavy, achy feeling in her leg, which has been reported in patients with breast cancer before swelling occurred (Armer, Radina, Porock, & Culbertson, 2003). Pain assessment is crucial in helping patients to cope. An over-the-counter medication may suffice, but some patients may need prescription-strength pain medication, making individual assessment critical.

H.F. stated that her pace was slower in her walks. In patients with breast cancer, fatigue often is a troublesome symptom affecting quality of life (Armer & Porock, 2002). Pacing activities or decreasing distances may help to maintain stamina. Pacing also may deter swelling that is associated with strenuous or long-distance exercise. The need for sleep medication should be evaluated because insomnia caused by leg discomfort or worry may contribute to fatigue.

Changes in wardrobe often are necessary when swelling occurs (Ryan, Stainton, Jaconelli, et al., 2003). Alteration in body image may result in changes to regular social activities and may lead to social isolation (Tobin, Lacey, Meyer, & Mortimer, 1993). Referrals to support groups or individual therapy sessions may be indicated depending on patient preference. H.F. found that she gained much by participating in a support group and thereby moved from one type of social interaction to another. Healthcare professionals must be sensitive to lifestyle changes as well as the financial burden that may result from a forced change in wardrobe.

With increased survival after cancer treatment, the long-term sequelae caused by cancer treatment should be recognized and treated. Patients must be informed about the potential lifelong side effects of treatment. Although H.F. was informed about the possibility of lymphedema development, many patients have reported that they were not informed about this life-alterating condition until they developed symptoms (Beesley, Janda, Eakin, Obermair, & Battistutta, 2007; Ryan, Stainton, Jaconelli, et al., 2003). Continued research is needed to determine the best interventions to decrease the side effects of treatment and maximize quality of life.

Author Contact

Kathleen Appollo, RN, BSN, OCN can be reached at appollok @mskcc.org, with copy to editor at ONF Editor@ons.org.

References

Abu-Rustum, N.R., Alektiar, K., Iasonos, A., Lev, G., Sonoda, Y., Aghajanian, C., et al. (2006). The incidence of lower-extremity lymph- edema following treatment of uterine corpus malignancies: A 12 year experience at Memorial Sloan-Kettering Cancer Center. Gynecologic Oncology, 103, 714–718. Armer, J.M., & Porock, D. (2002). Self-manage- ment of fatigue among women with lymph- edema. Lymphology, 35(Suppl.), 208–213. Armer, J.M., Radina, M.E., Porock, D., & Culbert- son, S.D. (2003). Predicting breast cancer-relat- ed lymphedema using self-reported symptoms. Nursing Research, 52, 370–379. Beesley, V., Janda, M., Eakin, E., Obermair, A., & Battistutta, D. (2007). Lymphedema after gynecological cancer treatment: Prevalence, correlates, and supportive care needs. Cancer, 109, 2607–2614. Brewer, V.H., Hahn, K.A., Rohrbach, B.W., Bell, J.L., & Baddour, L.M. (2000). Risk fac- tor analysis for breast cellulitis complicating breast conservation therapy. Clinical Infectious Diseases, 31, 654–659. Casely-Smith, J., & Casely-Smith, J. (1997). Modern treatment for lymphedema (5th ed.). Adelaide, Australia: Bowden Printing. Cheville, A.L., McGarvey, C.L., Petrek, J.A., Russo, S.A., Thadiens, S.R., & Taylor, M.E. (2003). Lymphedema management. Seminars in Radiation Oncology, 13, 214–225. Foldi, E. (1998). The treatment of lymphedema. Cancer, 83(Suppl. 12), 2833–2834. International Society of Lymphology. (2003). The diagnosis and treatment of peripheral lymphedema: Consensus document of the Inter- national Society of Lymphology. Lymphology, 36(2), 84–91. Kwan, W., Jackson, J., Weir, L.M., Dingee, C., McGregor, G., & Olivotto, I.A. (2002). Chronic arm morbidity after curative breast cancer treatment: Prevalence and impact on quality of life. Journal of Clinical Oncology, 20, 4242–4248. Lerner, R. (1998). Complete decongestive phys- iotherapy and the Lerner Lymphedema Ser- vices Academy of Lymphatic Studies. Cancer, 83(Suppl. 12), 2861–2863. Mortimer, P.S. (1998). The pathophysiology of lymphedema. Cancer, 83(Suppl. 12), 2798– 2802. National Lymphedema Network. (2005). The National Lymphedema Network. Retrieved August 11, 2007, from http://www.lymphnet .org Nunns, D., Williamson, K., Swaney, L., & Davy, M. (2000). The morbidity of surgery and adjuvant radiotherapy in the management of endometrial carcinoma. International Journal of Gynecologic Cancer, 10, 233–238. Ridner, S.H. (2002). Breast cancer lymphedema: Pathophysiology and risk reduction guidelines. Oncology Nursing Forum, 29, 1285–1293. Ryan, M., Stainton, M.C., Jaconelli, C., Watts, S., Mackenzie, P., Mansberg, T., et al. (2003). The experience of lower limb lymphedema for women after treatment for gynecologic cancer. Oncology Nursing Forum, 30, 417–423. Ryan, M., Stainton, M.C., Slaytor, E.K., Jaconelli, C., Watts, S., & Mackenzie, P. (2003). Aetiology and prevalence of lower limb lymphoedema following treatment for gynaecological cancer. Australia and New Zealand Journal of Obstet- rics and Gynaecology, 43, 148–151. Tobin, M.B., Lacey, H.J., Meyer, L., & Mortimer, P.S. (1993). The psychological morbidity of breast cancer-related arm swelling. Cancer, 72, 3248-3252

MetaPress

Risk factors for lower limb lymphedema after lymph node dissection in patients with ovarian and uterine carcinoma.

BMC Cancer. 2009 Feb

Tada H, Teramukai S, Fukushima M, Sasaki H. Department of Clinical Trial Design and Management, Translational Research Center, Kyoto University Hospital, Sakyo-ku, Kyoto, Japan. haru.ta@kuhp.kyoto-u.ac.jp

BACKGROUND: Lymph node dissection has proven prognostic benefits for patients with ovarian or uterine carcinoma; however, one of the complications associated with this procedure is lymphedema. We aimed to identify the factors that are associated with the occurrence of lymphedema after lymph node dissection for the treatment of ovarian or uterine carcinoma.

METHODS: A total of 694 patients with histologically confirmed ovarian (135 patients) or uterine cancer (258 with cervical cancer, 301 with endometrial cancer) who underwent lymph node dissection were studied retrospectively. Logistic regression analyses were used to identify the risk factors associated with occurrence of lymphedema. RESULTS: Among ovarian and uterine cancer patients who underwent pelvic lymph node dissection, post-operative radiotherapy (odds ratio: 1.79; 95% confidence interval: 1.20-2.67; p = 0.006) was statistically significantly associated with occurrence of lymphedema.

CONCLUSION: There was no relationship between any surgical procedure and occurrence of lymphedema among patients undergoing pelvic lymphadenectomy. Our findings are supported by a sound biological rationale because they suggest that limb lymphedema is caused by pelvic lymph node dissection.

Full Text Article

BioMed

Risk factors for postoperative lower-extremity lymphedema in endometrial cancer survivors who had treatment including lymphadenectomy.

Oct 2010

Todo Y, Yamamoto R, Minobe S, Suzuki Y, Takeshi U, Nakatani M, Aoyagi Y, Ohba Y, Okamoto K, Kato H.

Source Division of Gynecologic Oncology, National Hospital Organization, Hokkaido Cancer Center, Sapporo, Japan.

Abstract

OBJECTIVE: The aim of this study was to determine the incidence rate of lower-extremity lymphedema after systematic lymphadenectomy in patients with uterine corpus malignancies and to elucidate risk factors for this type of lymphedema.

METHODS: A retrospective chart review was carried out for all patients with uterine corpus malignant tumor managed at Hokkaido Cancer Center between 1991 and 2007. Patients who did not undergo lymphadenectomy as a treatment or died of cancer/intercurrent disease were excluded from this study. All living patients included in this study had hysterectomy, bilateral salpingo-oophorectomy and lymphadenectomy and their medical records were reviewed. We identified patients with postoperative lower-extremity lymphedema (POLEL). Logistic regression analysis was used to select the risk factors for POLEL.

RESULTS: Of 286 patients evaluated, 103 (37.8%) had POLEL. Multivariate analysis confirmed that adjuvant radiation therapy (OR=5.2, 95% CI=2.1-12.7), resection of more than 31 lymph nodes (OR=2.6, 95% CI=1.4-4.9), and removal of circumflex iliac nodes to the distal external iliac nodes (CINDEIN) (OR=6.1, 95% CI=1.3-28.2) were independent risk factors for POLEL.

CONCLUSION: Adjuvant radiation therapy should be avoided in patients who undergo systematic lymphadenectomy if an alternative postoperative strategy is possible. Although reducing the number of resected lymph nodes is not appropriate from a therapeutical point of view, elimination of CINDEIN dissection may be helpful in reducing the incidence of POLEL. The clinical significance of CINDEIN dissection needs to be investigated by a randomized controlled trial.

Elsevier

Lymphedema in Gynecologic Cancer Survivors: An Area for Exploration?

NIH

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